TGF-β1 signaling plays a pivotal role in the arrhythmogenicity of cardiac myofibroblasts and may be an important factor in arrhythmogenesis of the fibrotic heart.
BACKGROUND: alters the electrophysiological phenotype of myofibroblasts and cardiomyocytes and whether it affects proarrhythmic myofibroblast-cardiomyocyte crosstalk observed in vitro. METHODS AND RESULTS: signaling completely abolished both arrhythmogenic conditions. CONCLUSIONS: may play a potentially important role in arrhythmogenesis of the fibrotic heart.
Salvarani et al. (Mon,) studied this question.