Therapeutic potential of 4-OH-coumarin in neuroblastoma: cellular, molecular, and epigenetic insights.

Key Points

• To explore the cellular, molecular, and epigenetic effects of 4-OH-coumarin in neuroblastoma.
• Evaluated expressions of Parkin and piR-651 in HUVEC cells.
• Analyzed cellular and molecular pathways influenced by 4-OH-coumarin.
• Conducted experiments focusing on epigenetic modifications from secondary metabolites.
• Parkin and piR-651 expressions significantly increased in HUVEC cells (p<0.001).
• 4-OH-coumarin shows potential as a therapeutic agent in cancer treatment.
• Further research needed to confirm these effects in neuroblastoma models.