Polyurethane-based targeted active nanocarriers for colon cancer treatment

Key Points

• The study aims to evaluate the efficacy of polyurethane-based targeted nanocarriers for colon cancer treatment.
• Flow cytometry analysis was conducted to assess cell viability.
• Sustained drug release over 19 days was measured in release studies.
• CUR-loaded nanoparticles and their conjugates were tested for their impact on HT-29 cell viability.
• CUR-loaded nanoparticles reduced HT-29 cell viability to 66.35%.
• FO conjugation further decreased cell viability to 52.74%.
• The FO-CUR-TPU-OLE-PEG nanoparticle system shows potential as a targeted treatment alternative.