Concomitant mitral valve repair during CABG for moderate ischemic mitral regurgitation was associated with lower all-cause mortality compared to isolated CABG (HR 0.41; 95% CI 0.22-0.79; P=0.006).
Cohort (n=650)
Does CABG with mitral valve repair reduce all-cause mortality compared to isolated CABG in patients with moderate ischemic mitral regurgitation?
In patients with moderate ischemic mitral regurgitation, adding mitral valve repair to CABG was associated with significantly lower all-cause mortality and MACCE, though with increased perioperative morbidity.
Effect estimate: HR 0.41 (95% CI 0.22-0.79)
p-value: p=0.006
BACKGROUND The surgical management of moderate ischemic mitral regurgitation (IMR) in patients undergoing coronary artery bypass grafting (CABG) remains controversial, with limited real-world evidence, particularly from Asian populations. METHODS We retrospectively analyzed 650 patients with moderate IMR who underwent isolated CABG (n=493) or CABG with mitral valve repair (n=157) between August 2009 and April 2024. Inverse probability of treatment weighting was applied to adjust for baseline differences. The primary endpoint was all-cause mortality; the secondary endpoint was major adverse cardiovascular and cerebrovascular events. RESULTS During a median follow-up of 36.6 months, CABG with mitral valve repair was associated with lower all-cause mortality (multivariable HR, 0.41; 95%CI, 0.22-0.79; weighted log-rank P=0.006) and fewer composite events (weighted log-rank P=0.001), mainly driven by fewer deaths and rehospitalizations for heart failure. Findings were consistent across sensitivity and subgroup analyses. Echocardiographic follow-up (median 11.6 months) showed greater improvement in mitral regurgitation (75.4% vs 50.4%, P<0.001) and a larger reduction in left ventricular end-diastolic diameter (4.00, 7.8 vs 3.0-1.0, 6.0, P = 0.026). CABG with repair was associated with longer postoperative intubation, intensive care unit stay, and an increased risk of acute kidney injury, without increased early mortality. CONCLUSIONS In one of the largest Asian real-world cohorts, concomitant mitral valve repair during CABG for moderate IMR was associated with lower mortality and fewer major adverse cardiovascular and cerebrovascular events and greater echocardiographic improvement, but at the expense of increased perioperative morbidity.
Chen et al. (Sun,) conducted a cohort in Moderate ischemic mitral regurgitation (n=650). CABG with mitral valve repair vs. Isolated CABG was evaluated on All-cause mortality (HR 0.41, 95% CI 0.22-0.79, p=0.006). Concomitant mitral valve repair during CABG for moderate ischemic mitral regurgitation was associated with lower all-cause mortality compared to isolated CABG (HR 0.41; 95% CI 0.22-0.79; P=0.006).