Does IV r-tPA cause cardiac complications in patients with acute ischemic stroke and recent or concurrent MI?
IV r-tPA for acute ischemic stroke appears safe in patients with recent non-STEMI, but caution is advised for those with a STEMI in the preceding week.
=0.335). No non-STEMI patients receiving IV r-tPA had cardiac complications. Conclusions- In patients with AIS and recent or concurrent MI, MI type and the time elapsed between the 2 events should be taken into consideration when deciding to deliver IV r-tPA. Although recent non-STEMI or concurrent events seem safe, STEMI in the week preceding stroke should prompt caution. The low number of events and publication bias may have influenced our conclusions.
Marto et al. (Thu,) studied this question.