This methodological paper outlines when physiological fluoride-free solutions offer advantages over fluoride-containing solutions in high throughput automated patch clamp experiments.
1 expressed in CHO cells. We describe the advantages and disadvantages of using fluoride and provide examples of where fluoride can be used, where caution should be exerted and where fluoride-free solutions provide an advantage over fluoride-containing solutions.
Rapedius et al. (Mon,) studied this question.