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Sneha Kalpanas in Ayurvedic medicine are very effective and unique preparations. In classics, for single formula- tion many indications are stated. For same preparation, some of ingredients are altered in various Samhitas. For a single disease, exact same protocol of treatment cannot be followed. Because treatment protocol will be based on many factors, treatment has to be employed by looking into the involvement of Dosha, Dooshya (tissues) and based on the diseased condition of a patient. In such condition, Yukti (reasoning capacity) of a physician plays important role. Panchatikta Guggulu Ghrita (PTG Ghrita) is one unique formulation which has many indications stated in different Ayurvedic classics. The utility of this medicine can be made by looking into classics thoroughly and analyzing the condition of a patient. PTG Ghrita is indicated in almost all Dhatu and all Srotogata vyadhis (Systemic diseases). PTG Ghrita can be used as Sneha Drava, as a Shodhanaga sneha (oleation in purificatory therapies), as a Shamananga sneha (oleation in Palliative treatment) and also it can be used as Sneha Dravya in Basti dravya (drugs in Enema therapy). Keywords: PTG Ghrita, Panchatikta Guggulu Ghrita, Panchatikta Ghrita Guggulu, Asti-MajjagataVataVikara,
Shivananda B Karigar (Tue,) studied this question.