Diverse Structural Roles of Ferrocene in Mediating Ferroptosis Induction by ML162

Key Points

• This research aims to explore how ferrocene influences the induction of ferroptosis through GPX4 modulation.
• Investigation of diverse structural roles of ferrocene derivatives.
• Examination of iron-dependent cell death processes using in vitro models.
• Ferrocene derivatives significantly enhance ferroptosis induction.
• Covalent inhibitors targeting GPX4 reduce cell resistance to iron-induced death.