Over-Intake of Plant-Derived Antioxidants, H2S Generation, and Reductive Stress. Comment on Manzano-Pech et al. The Chronic Elevated Consumption of Hibiscus sabdariffa Linnaeus Results in Kidney Damage Associated with Excess H2S. Int. J. Mol. Sci. 2026, 27, 2190

Key Points

• The aim is to evaluate the effects of high hibiscus intake on hydrogen sulfide levels and kidney damage due to reductive stress.
• Analysis of oxidative and reductive stress markers in relation to hibiscus sabdariffa consumption.
• Evaluation of kidney function and damage indicators in relation to hydrogen sulfide generation.
• Elevated hydrogen sulfide levels were associated with kidney damage.
• Transition from reductive stress to oxidative stress was observed with increased antioxidant intake.