A 3-miRNA signature (miR-17-5p, miR-21-5p, miR-92a-3p) improved the identification of coronary macrovascular disease beyond clinical models and linked to specific coronary dysfunction patterns.
Observational
Does plasma miRNA profiling improve the identification of coronary macrovascular dysfunction compared to clinical models?
A specific 3-miRNA signature in plasma can improve the identification of coronary macrovascular dysfunction beyond standard clinical models.
Aim of the studyTo identify plasma miRNA profiles associated with macrovascular and/or microvascular patterns of coronary dysfunction. Main findingsA 3-miRNA signature (miR-17-5p, miR-21-5p, miR-92a-3p) improved the identification of macrovascular disease beyond clinical models, and unsupervised clustering identified distinct miRNotypes linked to specific coronary dysfunction patterns. ConclusionsPlasma miRNA-based molecular phenotyping could potentially complement existing clinical tools aiding in the identification of coronary macrovascular dysfunction.
Matute-Blanco et al. (Fri,) conducted a observational in Coronary macrovascular and microvascular dysfunction. Plasma miRNA profiles (3-miRNA signature) vs. Clinical models was evaluated on Identification of macrovascular disease. A 3-miRNA signature (miR-17-5p, miR-21-5p, miR-92a-3p) improved the identification of coronary macrovascular disease beyond clinical models and linked to specific coronary dysfunction patterns.