Epicardial global circumferential strain correlated significantly with serum FGF23 concentration in patients with type 2 diabetes, suggesting FGF23 as a potential early marker of myocardial damage.
Observational (n=71)
Does serum FGF23 level correlate with subclinical myocardial damage assessed by 2DSTE in patients with T2DM?
FGF23 may serve as an early diagnostic marker of subclinical myocardial damage in patients with type 2 diabetes.
Two-dimensional speckle-tracking echocardiography (2DSTE) detects myocardial dysfunction despite a preserved left ventricular ejection fraction. Fibroblast growth factor 23 (FGF23) has become a promising biomarker of cardiovascular risk. This study aimed to determine whether FGF23 may be used as a marker of myocardial damage among patients with diabetes mellitus type 2 (T2DM) and no previous history of myocardial infarction. The study enrolled 71 patients with a median age of 70 years. Laboratory data were analyzed retrospectively. Serum FGF23 levels were determined using a sandwich enzyme-linked immunosorbent assay. All patients underwent conventional echocardiography and 2DSTE. Baseline characteristics indicated that the median time elapsed since diagnosis with T2DM was 19 years. All subjects were divided into two groups according to left ventricular diastolic function. Individuals with confirmed left ventricular diastolic dysfunction had significantly lower levels of estimated glomerular filtration rate and higher values of hemoglobin A1c. Global circumferential strain (GCS) was reduced in the majority of patients. Only an epicardial GCS correlated significantly with the FGF23 concentration in all patients. The study indicates that a cardiac strain is a reliable tool for a subtle myocardial damage assessment. It is possible that FGF23 may become an early diagnostic marker of myocardial damage in patients with T2DM.
Kurpas et al. (Thu,) conducted a observational in Type 2 diabetes mellitus without previous myocardial infarction (n=71). Fibroblast growth factor 23 (FGF23) measurement vs. Left ventricular diastolic function groups was evaluated on Correlation between FGF23 concentration and epicardial global circumferential strain. Epicardial global circumferential strain correlated significantly with serum FGF23 concentration in patients with type 2 diabetes, suggesting FGF23 as a potential early marker of myocardial damage.