Co/Salox-Catalyzed Enantioselective C–H Annulation for One-Step Generation of C–N Axial and C Central Chirality

Key Points

• This research aims to establish a method for the one-step generation of chiral C-N axes and carbon central chirality.
• Developed a catalytic protocol using (quinoline-8-yl)benzamides and strained bicyclic alkenes.
• Performed reactions with metal oxidants or alternative conditions like photoredox catalysis.
• Examined double enantioinduction effects on chirality control.
• Achieved efficient enantioselective C–H annulation with low rotational barriers.
• Successfully generated both C-N axial and C central chirality.
• Showed the feasibility of different oxidation methods in this catalytic process.