A BSTRACT Introduction: Multidrug-resistant (MDR) bacteria commonly cause hospital-acquired infections (HAIs) in critically ill patients, leading to significant morbidity and mortality. These infections are difficult to treat and financially burdensome for patients. ICU patients are at higher risk of HAIs from antimicrobial-resistant pathogens. Materials and Methods: This 1-year prospective study in the Department of Microbiology included surgical ICU patients with bacterial infections after 48 hours of admission. Samples were collected based on clinical suspicion and processed per standard protocols. Isolates were classified as MDR, XDR, or PDR, and infections were categorized as hospital-acquired (HA) or community-acquired (CA), monomicrobial, or polymicrobial. The study also compared ICU stay and mortality in patients with and without nosocomial infections. Results: During the study, nosocomial infections occurred in 132 of 1010 patients (13% infection rate). A total of 151 infections and 165 isolates were identified, with respiratory tract infections being the most common, followed by body fluid infections. Klebsiella spp. (27.3%), Escherichia coli (22.4%), and Acinetobacter baumannii (20%) were the most frequent isolates. of the isolates, 89.6% were MDR, 77.5% XDR, and 2.8% PDR. Sepsis and bloodstream infections were key factors contributing to mortality in patients with hospital-acquired infections. Conclusion: The high incidence of MDR Gram-negative infections in the surgical ICU highlights the need for more stringent measures to control the spread of nosocomial pathogens.
Kaur et al. (Fri,) studied this question.
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