Genesis Human Proteome Scan: First Systematic Application of the Lo-Shu/Markov-Fiedler Geometric Framework to 20,158 Human Proteins — Druggability, Allosteric Prioritization, and Spectral Boundary Analysis

We apply the Lo-Shu/Markov-Fiedler geometric framework (validated at AUC=0. 882, permutation p=0. 005; DOI: 10. 5281/zenodo. 20153617) to a proteome-wide scan of the complete reviewed human proteome (UniProt, 20, 431 proteins). Using AlphaFold v4 C-alpha structures, 20, 158 proteins (98. 66%) were processed in 72. 3 minutes (0. 21 s/protein, 8-thread parallel). Three prioritized candidate lists are reported: (1) Top druggable proteins (drugₛcore=1. 0): includes E2F8, RBM47, ESYT2/3, SHTN1, ARHGAP10 — all with lambda₂ 0. 30), consistent with their two-domain alpha/beta cluster architecture and known allosteric metal-sensing behavior. Cross-list analysis identifies MT1M (Q8N339) as a dual allosteric + spectral boundary candidate. All analyses use C-alpha only with no ligand information. Full 20, 158-row dataset available upon request.