= 0.061). ROC analysis showed that NLR, MLR, SII, SIRI, and PIV had statistically significant but poor to modest discriminatory ability for late-stage osteoarthritis. Although SIRI showed the highest AUC among the evaluated indices, its performance remained within the modest range, and none of the markers demonstrated clinically meaningful discriminatory ability. In multivariable binary logistic regression analysis adjusted for age and gender, NLR, MLR, SII, SIRI, and PIV remained associated after adjustment for age and gender with late-stage osteoarthritis.ConclusionNLR, MLR, SII, SIRI, and PIV were associated with greater radiographic severity in knee osteoarthritis. Among the investigated biomarkers, SIRI, PIV, and SII showed relatively better discriminatory performance than the other indices; however, the overall ability of all markers to distinguish early-stage from late-stage osteoarthritis was limited. These findings suggest that CBC-derived inflammatory indices may serve as inexpensive adjunctive markers of radiographic severity, but they should not be used as stand-alone tools in clinical decision-making.
Yolaçan et al. (Fri,) studied this question.