Pulse Entdecken nav.journalClub Debatten Trends Forschende Zeitschriften

Join discussions, follow papers, and never miss your next session.

Download on theApp Store

Start Entdecken nav.journalClub Trends

⌘+K

Upregulation of ADAM10 reinforces CD8 + T cells toward exhaustion in the TME | Synapse

May 15, 2026International Reviews of Immunology1 citations

View Full Paper

Upregulation of ADAM10 reinforces CD8 + T cells toward exhaustion in the TME

AAAhmed M. E. AbdallaUniversity of Jinan YMYu MiaoGansu Provincial Hospital YTYasir A TahaNajran University

Key Points

Investigate the role of ADAM10 in the function of CD8+ T cells within the tumor microenvironment.
Utilized in vivo models of solid tumors to assess CD8+ T cell functionality.
Analyzed the impact of ADAM10 upregulation on T cell exhaustion in the TME.
Upregulation of ADAM10 significantly increased markers of CD8+ T cell exhaustion.
Cytotoxic function of CD8+ T cells was markedly inhibited in the presence of an immunosuppressive TME.

Abstract

Using cytotoxic CD8 In solid tumors, the presence of an immunosuppressive tumor microenvironment (TME) inhibits the effectiveness of cytotoxic CD8

KI fragen

Like

Bookmark

Share

View Full Paper

Cite This Study

Abdalla et al. (Wed,) studied this question.

synapsesocial.com/papers/6a06b95be7dec685947ac069 https://doi.org/https://doi.org/10.1080/08830185.2026.2669732

KI fragen

Like

Bookmark

Share

View Full Paper