Obstructive hypertrophic cardiomyopathy management with guideline-recommended therapies still resulted in increasing heart failure, and 27.7% of patients required reintervention after septal reduction.
Cohort (n=8,791)
Yes
Real-world data shows that despite guideline-directed therapy, oHCM patients experience increasing disease burden and high rates of reintervention after septal reduction therapy, highlighting the need for new treatments.
Obstructive hypertrophic cardiomyopathy (oHCM) has been studied primarily in comprehensive centers of excellence. Broadening the understanding of patients with oHCM in the general population may improve identification and treatment in other settings. This retrospective cohort study identified adults with oHCM from a large electronic medical record database comprising data from 39 integrated delivery networks (IBM Explorys; observational period: January 2009-July 2019). Clinical characteristics, healthcare resource utilization (HCRU), and outcomes were reported. Of 8791 patients, 53.0% were female and the mean index age was 61.8 years. Cardiovascular drugs prescribed included beta-blockers (80.5%), calcium channel blockers (46.0%), and disopyramide (2.4%). Over time, heart failure, atrial fibrillation, and ventricular arrhythmias increased. Surgical procedures included septal myectomy (22.0%), alcohol septal ablation (0.6%), and heart transplantation (0.3%). Implantable cardioverter defibrillators were present in 11.2% of patients. After initial septal reduction therapy (SRT), HCRU increased and 550 patients (27.7%) required a reintervention. Of the overall group, 2.7% experienced sudden cardiac arrest by end of study. In conclusion, this cohort of patients with oHCM had guideline-recommended drug therapy and procedures. Despite this, heart failure, atrial fibrillation, and ventricular arrhythmias increased, and more than a quarter of patients undergoing SRT required reintervention. These unresolved issues emphasize the unmet need for new, effective therapies for patients with oHCM.
Butzner et al. (Mon,) conducted a cohort in Obstructive hypertrophic cardiomyopathy (n=8,791). Guideline-recommended therapy and procedures was evaluated on Clinical characteristics, healthcare resource utilization, and outcomes. Obstructive hypertrophic cardiomyopathy management with guideline-recommended therapies still resulted in increasing heart failure, and 27.7% of patients required reintervention after septal reduction.