Pulsed field ablation for pulmonary vein isolation using standard sedation resulted in a 9% atrial tachyarrhythmia recurrence rate and a 19% rate of silent cerebral injury.
Observational (n=191)
Does pulsed field ablation using standard sedation provide safe and effective pulmonary vein isolation in patients with atrial fibrillation?
Pulsed field ablation for pulmonary vein isolation using standard sedation is feasible, safe, and associated with a low short-term recurrence rate of atrial tachyarrhythmias.
BACKGROUND: Pulsed field ablation represents an energy source specific for ablation of cardiac arrhythmias including atrial fibrillation. The aim of the study was to describe the adoption and the process of streamlining procedures with a new ablation technology. METHODS: All-comer atrial fibrillation patients (n=191; mean age 69±12 years) underwent catheter ablation with a pulsed field ablation ablation device exclusively using analog-sedation. In the validation phase (n=25), device electrogram quality was compared with a circular mapping catheter to assess pulmonary vein isolation and esophageal temperature monitoring was used. In the streamline phase (n=166), a single-catheter approach was implemented. Postprocedural cerebral magnetic resonance imaging was performed in 53 patients. In 52 patients, esophageal endoscopy was performed at day 1 after the procedure. Follow-up was performed using 72 hours Holter ECGs. RESULTS: =0.004), no further strokes and a low incidence of silent cerebral injury (10/53 patients; 19%) were noted. During short-term follow-up, 17/191 patients (9%) had a atrial tachyarrhythmia recurrence. CONCLUSIONS: The pulsed field ablation device allows for simple and safe simple single shot pulmonary vein isolation using standard sedation protocols. Procedural speed and efficacy are remarkable and streamlining measures have added safety.
Schmidt et al. (Thu,) conducted a observational in Atrial fibrillation (n=191). Pulsed field ablation was evaluated on Atrial tachyarrhythmia recurrence. Pulsed field ablation for pulmonary vein isolation using standard sedation resulted in a 9% atrial tachyarrhythmia recurrence rate and a 19% rate of silent cerebral injury.