ABSTRACT Maintaining high electrical conductivity in flexible, porous fiber mats without compromising breathability and mass transport remains a critical challenge for wearable and organ‐interfaced bioelectronics. Here, we report gold nanomesh–thermoplastic polyurethane (AuNM‐TPU) fiber mats that integrate conformal conductive networks within highly porous electrospun architectures. A catalyzed reduced‐rate electroless deposition strategy enables uniform, through‐thickness gold nanomesh formation while maintaining the porous fibrous network. The Au nanomesh uniformly coats TPU microfibers while preserving the intrinsic through‐thickness porous fibrous network and open pore pathways, resulting in high porosity retention (>89%). The AuNM‐TPU mats exhibit high water vapor transmission (∼95% of pristine TPU), stable molecular permeability, excellent mechanical stretchability, and stable electrical performance under repeated deformation. Electrochemical characterization demonstrates rapid electron‐transfer kinetics, low charge–transfer resistance, and an electrochemically active surface area 27 times greater than the geometric area, outperforming commercial gold mesh electrodes. As a functional demonstration, superoxide dismutase is immobilized onto the Au nanomesh via cysteine linkers to enable selective electrochemical detection of superoxide. The biosensor achieves a detection limit of 97 n m with strong resistance to common electroactive interferents. These results establish AuNM‐TPU as a breathable, mechanically resilient, and high‐performance nanomesh platform for soft bioelectronic and biosensing applications.
Batayneh et al. (Wed,) studied this question.