Microwave-Assisted Palladium-Catalyzed Threefold Domino Cyclization of 2-(2-(Phenylethynyl)phenyl)-1H-benzodimidazoles/indoles to Access Polycyclic Motifs

Key Points

• This research aims to develop an efficient method for synthesizing polycyclic structures using a palladium-catalyzed domino process under microwave conditions.
• Utilized microwave irradiation to enhance reaction efficiency.
• Employed a palladium catalyst for the domino cyclization process.
• Conducted three-fold cascade transformations to construct the desired polycyclic motifs.
• Demonstrated successful synthesis of polycyclic frameworks with high yields.
• Achieved faster reaction times compared to traditional methods.
• Established a functional protocol applicable for various substrates.