Human adult adipose tissue, obtained from routine liposuction, can directly generate functional organoids spanning all three germ layers without single-cell isolation or genetic manipulation. In the landmark study discussed here, Huang et al. demonstrate tri-lineage competence from a single unmanipulated tissue source. Specifically, reaggregated microfat pellets give rise to mesodermal bone marrow organoids that reconstitute human hematopoiesis, endodermal insulin-producing organoids that reverse hyperglycemia in diabetic mice, and ectodermal neural-like tissues. Together, these findings suggest a tissue-centric paradigm that may offer a simpler and potentially scalable route from adipose tissue to regenerative therapy.
Bai et al. (Thu,) studied this question.