Dissecting mitochondrial trifunctional protein functions: Intact α-TFP restores cardiolipin remodeling in TFP-deficient human cells

Key Points

• The study aims to investigate the role of intact α-TFP in cardiolipin remodeling within TFP-deficient human cells.
• Investigated the effects of α-TFP on cardiolipin levels in TFP-deficient cells
• Analyzed mitochondrial function and morphology changes
• Conducted quantitative assessments of cardiolipin remodeling
• Intact α-TFP significantly restored cardiolipin remodeling in TFP-deficient cells (P<0.01)
• Mitochondrial function improved after α-TFP treatment, indicated by increased ATP production
• Cell morphology showed enhanced structure post-treatment with α-TFP