Knockout of SORBS2 protein disrupts intercalated disc structural integrity and manifests features of arrhythmogenic cardiomyopathy, supporting its role as a new ACM-susceptibility gene.
SORBS2 is identified as a potential new susceptibility gene for arrhythmogenic cardiomyopathy, with its knockout disrupting intercalated disc structural integrity.
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as a new ACM-susceptibility gene is supported by preliminary human genetics study, future validation in larger cohorts with ACM is needed.
Ding et al. (Tue,) reported a other. Knockout of SORBS2 protein disrupts intercalated disc structural integrity and manifests features of arrhythmogenic cardiomyopathy, supporting its role as a new ACM-susceptibility gene.