Chronic heart failure due to dilated cardiomyopathy is associated with disorganized and increased cytoskeletal proteins, alongside significantly decreased contractile myofilaments.
In chronic heart failure due to dilated cardiomyopathy, there is a disorganization and accumulation of cytoskeletal proteins alongside a decrease in contractile myofilaments, providing a morphological basis for reduced contractile function.
The cytoskeleton of cardiac myocytes consists of actin, the intermediate filament desmin and of aand b-tubulin that form the microtubules by polymerization. Vinculin, talin, dystrophin and spectrin represent a separate group of membrane-associated proteins. In numerous experimental studies, the role of cytoskeletal alterations especially of microtubules and desmin, in cardiac hypertrophy and failure (CHF) has been described. Microtubules were found to be accumulated thereby posing an increased load on myocytes which impedes sarcomere motion and promotes cardiac dysfunction. Other groups were unable to confirm microtubular densification. The possibility exists that these changes are species, load and chamber dependent. Recently, damage of the dystrophin molecule and MLP (muscle LIM protein) were identified as possible causes of CHF. Our own studies in human hearts with chronic CHF due to dilated cardiomyopathy (DCM) showed that a morphological basis of reduced contractile function exists: the cytoskeletal and membraneassociated proteins are disorganized and increased in amount confirming experimental reports. In contrast, the contractile myofilaments and the proteins of the sarcomeric skeleton including titin, a-actinin, and myomesin are significantly decreased. These changes can be assumed to occur in stages and are here presented as a testable hypothesis: (1) The early and reversible stage as present in animal experiments is characterized by accumulation of cytoskeletal proteins to counteract an increased strain without loss of contractile material.
S. Hein (Fri,) conducted a review in Cardiac hypertrophy and failure (CHF). Chronic heart failure due to dilated cardiomyopathy is associated with disorganized and increased cytoskeletal proteins, alongside significantly decreased contractile myofilaments.