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Abstract N ‐(difluoromethyl)amino (−NCF 2 H) compounds are of great interest given their unique and underexplored physiochemical properties. The lack of structural diversity in NCF 2 H compounds is likely due in part to the shortage of protocols for efficient installation. Presented herein is a new shelf‐stable pyridinium reagent that enables the direct installation of the N ‐(difluoromethyl)sulfonamide moiety N(Ts)CF 2 H) onto (hetero)arenes and alkenes for the diversification of aryl and alkyl NCF 2 H compounds. The described protocol utilizes blue light photoredox catalysis and displays broad functional group tolerance with excellent chemoselectivity. Additional transformations and applicability towards a photoredox continuous flow protocol are also demonstrated.
Lin et al. (Fri,) studied this question.