Rosuvastatin significantly slowed progression of carotid IMT at 12 months compared with pravastatin (mean percentage change 1.91% vs 5.8%; P=0.004).
RCT (n=348)
Open-label, blinded-endpoint
Randomly assigned
Does rosuvastatin reduce progression of carotid intima-media thickness compared to pravastatin in adult Japanese patients with hypercholesterolemia?
Rosuvastatin is more effective than pravastatin in slowing the progression of carotid intima-media thickness in Japanese patients with hypercholesterolemia.
Effect estimate: Difference 3.89%
Absolute Event Rate: 1.91% vs 5.8%
p-value: p=0.004
BACKGROUND: A recent trial in Western countries has shown that rosuvastatin slows progression of carotid intima-media thickness (IMT) in patients with modest carotid IMT thickening and elevated levels of low-density lipoprotein cholesterol (LDL-C). We conducted a prospective, randomized, open-label, blinded-endpoint trial to determine whether rosuvastatin is more effective than pravastatin in slowing progression of carotid IMT in Japanese patients. METHODS AND RESULTS: Adult patients with hypercholesterolemia who had a maximum IMT ≥1.1mm were randomly assigned to receive rosuvastatin or pravastatin. The primary endpoint was the percent change in the mean-IMT, which was measured by a single observer who was blinded to the treatment assignments. The trial was stopped on April 2011 according to the recommendation by the data and safety monitoring committee. A total of 348 patients (173 rosuvastatin; 175 pravastatin) were enrolled and 314 (159 rosuvastatin; 155 pravastatin) were included in the primary analysis. Mean (SD) percentage changes in the mean-IMT at 12 months were 1.91% (10.9) in the rosuvastatin group and 5.8% (12.0) in the pravastatin group, with a difference of 3.89% (11.5) between the groups (P=0.004). At 12 months, 85 patients (59.4%) in the rosuvastatin group achieved a LDL-C/high-density lipoprotein cholesterol ratio ≤1.5 compared with 24 patients (16.4%) in the pravastatin group (P<0.0001). CONCLUSIONS: Rosuvastatin significantly slowed progression of carotid IMT at 12 months compared with pravastatin.
Nohara et al. (Wed,) conducted a rct in Hypercholesterolemia (n=348). Rosuvastatin vs. Pravastatin was evaluated on Percent change in the mean-IMT (Difference 3.89%, p=0.004). Rosuvastatin significantly slowed progression of carotid IMT at 12 months compared with pravastatin (mean percentage change 1.91% vs 5.8%; P=0.004).