Pulse wave imaging and fluid-structure interaction simulations demonstrated a high linear correlation between PWV² and E measurements (R² = 0.98), confirming the Moens-Korteweg relationship.
Does pulse wave imaging accurately estimate arterial stiffness as defined by the Moens-Korteweg relationship in simulated and in vitro models?
Pulse wave imaging combined with FSI simulations accurately estimates arterial stiffness, confirming the Moens-Korteweg relationship in vitro and in phantoms.
Effect estimate: R² = 0.98
Pulse wave imaging (PWI) is an ultrasound-based method for noninvasive characterization of arterial stiffness based on pulse wave propagation. Reliable numerical models of pulse wave propagation in normal and pathological aortas could serve as powerful tools for local pulse wave analysis and a guideline for PWI measurements in vivo. The objectives of this paper are to (1) apply a fluid-structure interaction (FSI) simulation of a straight-geometry aorta to confirm the Moens-Korteweg relationship between the pulse wave velocity (PWV) and the wall modulus, and (2) validate the simulation findings against phantom and in vitro results. PWI depicted and tracked the pulse wave propagation along the abdominal wall of canine aorta in vitro in sequential Radio-Frequency (RF) ultrasound frames and estimates the PWV in the imaged wall. The same system was also used to image multiple polyacrylamide phantoms, mimicking the canine measurements as well as modeling softer and stiffer walls. Finally, the model parameters from the canine and phantom studies were used to perform 3D two-way coupled FSI simulations of pulse wave propagation and estimate the PWV. The simulation results were found to correlate well with the corresponding Moens-Korteweg equation. A high linear correlation was also established between PWV² and E measurements using the combined simulation and experimental findings (R² = 0.98) confirming the relationship established by the aforementioned equation.
Shahmirzadi et al. (Mon,) conducted a other in Arterial stiffness. Pulse wave imaging (PWI) and fluid-structure interaction (FSI) simulations was evaluated on Correlation between PWV² and E measurements (R² = 0.98). Pulse wave imaging and fluid-structure interaction simulations demonstrated a high linear correlation between PWV² and E measurements (R² = 0.98), confirming the Moens-Korteweg relationship.
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