Early-onset pre-eclampsia requiring delivery before 34 weeks significantly increased the risk of cardiac diastolic dysfunction one year post-partum compared to normotensive pregnancies (RR 3.41).
Cohort (n=141)
No
Does severe pre-eclampsia increase the risk of persistent cardiac diastolic dysfunction at one year post-partum compared to normotensive pregnancies?
Early-onset severe pre-eclampsia is associated with a significantly increased risk of persistent cardiac diastolic dysfunction one year after delivery, highlighting the need for long-term cardiovascular screening in this high-risk population.
Effect estimate: RR 3.41 (95% CI 1.11-10.5)
Absolute Event Rate: 22.7% vs 6.67%
p-value: p=0.04
BACKGROUND: Pre-eclampsia is associated with significant changes to the cardiovascular system during pregnancy. Eccentric and concentric remodelling of the left ventricle occurs, resulting in impaired contractility and diastolic dysfunction. It is unclear whether these structural and functional changes resolve completely after delivery. AIMS: The objective of the study was to determine cardiac diastolic function at delivery and one year post-partum in women with severe pre-eclampsia, and to determine possible future cardiovascular risk. METHODS: This was a descriptive study performed at Steve Biko Academic Hospital, a tertiary referral hospital in Pretoria, South Africa. Ninety-six women with severe preeclampsia and 45 normotensive women with uncomplicated pregnancies were recruited during the delivery admission. Seventy-four (77.1%) women in the pre-eclamptic group were classified as a maternal near miss. Transthoracic Doppler echocardiography was performed at delivery and one year post-partum. RESULTS: At one year post-partum, women with pre-eclampsia had a higher diastolic blood pressure (p = 0.001) and body mass index (p = 0.02) than women in the normotensive control group. Women with early onset pre-eclampsia requiring delivery prior to 34 weeks' gestation had an increased risk of diastolic dysfunction at one year post-partum (RR 3.41, 95% CI: 1.11-10.5, p = 0.04) and this was irrespective of whether the patient had chronic hypertension or not. CONCLUSION: Women who develop early-onset pre-eclampsia requiring delivery before 34 weeks are at a significant risk of developing cardiac diastolic dysfunction one year after delivery compared to normotensive women with a history of a low-risk pregnancy.
Soma‐Pillay et al. (Mon,) conducted a cohort in Severe pre-eclampsia (n=141). Early-onset severe pre-eclampsia (<34 weeks) vs. Normotensive uncomplicated pregnancy was evaluated on Cardiac diastolic dysfunction at one year post-partum (RR 3.41, 95% CI 1.11-10.5, p=0.04). Early-onset pre-eclampsia requiring delivery before 34 weeks significantly increased the risk of cardiac diastolic dysfunction one year post-partum compared to normotensive pregnancies (RR 3.41).