African swine fever virus reorganizes endosome dynamics and redistributes endosomal membranes to the viral replication site to ensure a productive infection.
ASFV reorganizes endosome dynamics to ensure a productive infection by building a compact viral replication organelle.
African swine fever virus (ASFV) infection causes endosomal reorganization. Here, we show that the virus causes endosomal congregation close to the nucleus as the infection progresses, which is necessary to build a compact viral replication organelle. ASFV enters the cell by the endosomal pathway and reaches multivesicular late endosomes. Upon uncoating and fusion, the virus should exit to the cytosol to start replication. ASFV remodels endosomal traffic and redistributes endosomal membranes to the viral replication site. Virus replication also depends on endosomal membrane phosphoinositides (PtdIns) synthesized by PIKfyve. Endosomes could act as platforms providing membranes and PtdIns, necessary for ASFV replication. Our study has revealed that ASFV reorganizes endosome dynamics, in order to ensure a productive infection.
Cuesta-Geijo et al. (Thu,) conducted a other in African swine fever virus (ASFV) infection. African swine fever virus reorganizes endosome dynamics and redistributes endosomal membranes to the viral replication site to ensure a productive infection.