Captopril monotherapy increased HDL-cholesterol by 6.2% (P<0.01) and decreased triglycerides by 10.6% (P<0.05), whereas metoprolol decreased HDL by 5.6% and increased triglycerides by 10.3%.
RCT (n=104)
Single-blind
randomized
Yes
Does captopril compared to metoprolol improve blood lipids in patients with mild to moderate hypertension?
Captopril has a more favorable effect on blood lipids compared to metoprolol in patients with mild to moderate hypertension, though this benefit is attenuated when a thiazide diuretic is added.
In a 24-week randomized multicentre single-blind study, including mild to moderate hypertensives free from other diseases, the effect on blood lipids of captopril (n = 51) was studied and compared with that of metoprolol (n = 53). In order to keep the diastolic pressure less than 95 mm Hg, bendroflumethiazide was added to the medication for 11 patients in the captopril group and 11 patients in the metoprolol group. Neither captopril nor metoprolol altered total cholesterol significantly. Captopril as monotherapy increased HDL-cholesterol by 6.2% (P less than 0.01) and decreased triglycerides by 10.6% (P less than 0.05). Metoprolol as monotherapy decreased HDL-cholesterol by 5.6% (P less than 0.01) and increased triglycerides by 10.3% (P less than 0.05). When bendroflumethiazide was added the favourable effect of captopril on the blood lipids disappeared while the undesirable effect of metoprolol became more pronounced.
Foss et al. (Thu,) conducted a rct in mild to moderate hypertension (n=104). Captopril vs. Metoprolol was evaluated on blood lipids. Captopril monotherapy increased HDL-cholesterol by 6.2% (P<0.01) and decreased triglycerides by 10.6% (P<0.05), whereas metoprolol decreased HDL by 5.6% and increased triglycerides by 10.3%.