Design, Synthesis, and Evaluation of a Novel Phenanthrene Derivative as a Potential DNA Intercalator

Key Points

• The aim is to design and evaluate a novel phenanthrene derivative as a DNA intercalator for pharmacological applications.
• Designed and synthesized a phenanthrene-based derivative bearing cytosine moieties (PHE-CYT-3,6-TFA).
• Formulated the derivative as a trifluoroacetic acid salt to improve solubility in water.
• Developed a new compound that potentially serves as a DNA intercalator, which could have implications for drug development.