Premature heart disease mortality in US women <65 years increased between 2010 and 2018 (APC 0.53; 95% CI 0.18-0.89), narrowing the mortality gap with cancer.
Observational
Yes
The mortality gap between cancer and heart disease in women under 65 in the US is narrowing due to a recent increase in premature heart disease mortality rates.
Effect estimate: APC 0.53 (95% CI 0.18-0.89)
AIMS: To compare premature heart disease- and cancer-related deaths in women in the USA. METHODS AND RESULTS: We analysed the US national database of death certificates of women aged <65 from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research database between 1999 and 2018. We measured annual percentage changes (APCs) in age-adjusted mortality rates (AAMRs) and years of potential life lost per 100 000 persons due to heart disease and cancer. Overall, cancer was a more prevalent cause of premature death compared with heart disease. Between 1999 and 2018, the AAMRs decreased for both cancer (61.9/100 000 to 45.6/100 000) and heart disease (29.2/100 000 to 22.6/100 000). However, while APC in AAMR for cancer declined consistently over time, after an initial decline, APC in AAMR for heart disease increased between 2010 and 2018 0.53 95% confidence interval (0.18-0.89), with a significant rise in Midwest, medium/small metros, and rural areas after 2008. Compared with cancer, APC in AAMR for heart disease increased in women aged 25-34 years 2.24 (0.30-4.22); 2013-18) and 55-64 years [0.46 (0.13-0.80); 2009-13, as well as Non-Hispanic (NH) Whites APC, 0.79 (0.46-1.13); 2009-18 and NH American Indian/Alaskan Native 2.71 (0.59-4.87); 2011-2018. Consequently, the mortality gap between cancer and heart disease has narrowed from an AAMR of 32.7/100 000 to 23.0/100 000. CONCLUSIONS: The mortality gap between cancer and heart disease is decreasing among women <65 years. Intensive cardiovascular health interventions are required focusing on vulnerable young demographic subgroups and underserved regional areas to meet the American Heart Association's Impact Goal and Million Hearts Initiative.
Khan et al. (Wed,) conducted a observational in Premature heart disease- and cancer-related mortality. Heart disease vs. Cancer was evaluated on Annual percentage changes (APCs) in age-adjusted mortality rates (AAMRs) (APC 0.53, 95% CI 0.18-0.89). Premature heart disease mortality in US women <65 years increased between 2010 and 2018 (APC 0.53; 95% CI 0.18-0.89), narrowing the mortality gap with cancer.
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