Objective:To explore the epidemiological trend and prognostic factors of laryngeal cancer, constructs a nomogram based on prognostic factors to predict the overall and specific survival rate. Methods:Extract confirmed laryngeal cancer patients from the SEER database from 1975 to 2021 for epidemiological trend analysis. Simultaneously collect follow-up data and clinical data from 2012 to 2021. By using Cox regression, analyze the factors that affect patient overall and specific survival rate, and construct a nomogram. Results:From 1975 to 2021, the age adjusted incidence rate of laryngeal cancer decreased significantly. In different races, the age adjusted incidence rate of laryngeal cancer decreased significantly. In different age groups, the incidence rate of 15 to 44 years, 45-54 years and 55-64 years decreased most significantly. In different gender, the age adjusted incidence rate of laryngeal cancer decreased significantly in both men and women. By using Cox regression, independent risk factors affecting the overall and specific survival rate of laryngeal cancer patients were identified. These factors were used to construct a nomogram prediction model. The nomogram prediction model shows good consistency between the predicted values and actual values of overall and specific survival rate. Conclusions:This study found that from 1975 to 2021, the age adjusted incidence rate of laryngeal cancer decreased significantly. In addition, the nomogram prediction model for overal land specific survival rate of laryngeal cancer have high reference value, which can help physicians correctly evaluate the overall and specific survival rate of patients.
Abudoubari et al. (Thu,) studied this question.