Synthetic routes towards antiviral agents from the Houttuynoid family: Structure-activity relationships and antiviral efficacy against herpes simplex virus type 1

Key Points

• The research aims to explore synthetic methods for developing antiviral agents from houttuynoids and assess their effectiveness against herpes simplex virus type 1.
• Developed synthetic routes for houttuynoids
• Evaluated structure-activity relationships
• Tested antiviral efficacy against herpes simplex virus type 1
• Certain synthetic houttuynoids demonstrated significant antiviral activity
• Effectiveness varied based on structural modifications
• Outcomes suggest potential as new antiviral agents