Abstract Introduction Pulmonary hypertension is characterised by elevated pressures in the pulmonary circulation, and can lead to competing demands between pulmonary and systemic circulation during sepsis and septic shock. The association between Septicemia and Pulmonary hypertension (PH) remains unexplored. This study aimed to analyze mortality trends and demographic disparities in septicemia with PH using the CDC Wide-Ranging Online Data for Epidemiologic Research (CDC-WONDER) Multiple Causes of Death (MCD) database from 1999 to 2020. Methodology We analyzed MCD data from the CDC-WONDER database (1999-2020), identifying deaths in which both septicemia (A41.9) and PH (ICD-10:I27 and I27.2) were listed. Data were analyzed by urbanization, gender, race, geographic region, and place of death. Age-adjusted mortality rates (AAMR) and annual percentage change (APC) were calculated using statistical analysis, JointPoint regression software. Results There were over 18,000 deaths involving both septicemia and PH in the United States (US). The adjusted mortality rates increased in both females and males from 0.155 in 1999 to 0.737 in 2020, and from 0.116 in 1999 to 0.537 in 2020, respectively. The average annual percentage change (AAPC) in females and males from 1999 to 2020 was 7.15% and 7.5%, respectively; both were statistically significant (p 0.001). In females, the APC from 1999-2007, 2007-2020 were 10.61% and 5.07%, respectively. For males, APC from 1999-2020 was 7.5%, respectively. The highest number of deaths occurred in inpatient settings, followed by the nursing or long-term care facilities, and the hospice facility. There were a higher number of deaths in the White population, followed by Black or African Americans. Age-adjusted rates were highest in California, Texas, and Ohio and lowest in Alaska. AAPC was highest in Medium metropolitan areas, followed by micropolitan and small metropolitan areas. Conclusion Over two decades, mortality involving septicemia and PH increased with disparities involving sex, race, urban areas, and region. There are also increasing proportions of deaths occurring outside the inpatient settings at long-term care and hospice facilities, highlighting the need to study that population in detail. This underscores the importance of screening measures, management of both conditions, and increasing access to underserved areas. This abstract is funded by: None
Bhatt et al. (Fri,) studied this question.