What question did this study set out to answer?

The study aims to evaluate patient-reported outcomes across different interstitial lung disease types and identify associated factors.

May 20, 2026

C39-25 Patient-Reported Outcomes in Patients With Different Interstitial Lung Disease (ILD) Types

Key Points

The study aims to evaluate patient-reported outcomes across different interstitial lung disease types and identify associated factors.
Cross-sectional study conducted at Shanghai Chest Hospital from October 2019 to October 2024.
Evaluated characteristics and patient-reported outcomes using various validated questionnaires.
Used Analysis of Covariance (ANCOVA) to compare outcomes across different ILD types.
573 patients included, with CTD-ILD as the most prevalent subtype (41.9%).
KBILD total scores varied, with smoking-related ILD reporting the highest scores.
Lower KBILD scores correlated with higher ILD-GAP stages and oxygen use, while better FVC %pred and longer 6-minute walk distances improved scores.

Abstract

Abstract Background There are limited study on patient-reported outcomes (PROs) in different types of interstitial lung disease (ILD) patients. The study aimed to assess PROs across different types of ILD patients and investigate the influencing factors for PROs. Methods This cross-sectional study evaluated characteristics and PRO of ILD patients from Shanghai Chest Hospital between October 2019 and October 2024. ILD type were categorized idiopathic pulmonary fibrosis (IPF), connective tissue disease-associated ILD (CTD-ILD), idiopathic non-specific interstitial pneumonia (iNSIP), exposure-related ILD, smoking-related ILD, and other ILDs. Disease severity was assessed using the ILD-GAP staging. PROs were measured by the King’s Brief Interstitial Lung Disease questionnaire (KBILD) as quality of life (QOL), the Leicester Cough Questionnaire (LCQ), the cough visual analog scale (VAS), the modified Medical Research Council (mMRC) dyspnea scale, and the performance status (PS) scale. Analysis of covariance (ANCOVA) was used to compare PROs across ILD types. Results The analysis included 573 patients. CTD-ILD was the most prevalent subtype (41.9%), followed by IPF (20.1%), iNSIP(13.4%), smoking-related ILD(9.4%) , exposure-related ILD(6.5%) and others (8.7%). KBILD total scores varied significantly across ILD types, of which patients with smoking-related ILD reported the highest KBILD total scores. Higher ILD-GAP stage and oxygen use were associated with lower KBILD total and breathlessness domain scores, whereas better FVC %pred and longer 6-minute walk distance (6MWD) were linked to improved KBILD total and breathlessness domain scores. The ILD-GAP stage, 6MWD, and FVC% predicted showed significant associations with LCQ and cough-VAS, whereas a higher ILD-GAP stage and current oxygen use were positively correlated with mMRC scores. PS scores were influenced by 6MWD and the use of home oxygen therapy. Conclusion PROs vary across patients with different ILD types and are driven primarily by disease severity (ILD-GAP staging). This abstract is funded by: Shanghai Municipal Health Commission (No.20244Z0019), National Key Technologies R & D Program Precision Medicine Research (2024ZD0528901), Physician-scientist project of Shanghai Jiao Tong University School of Medicine (No.20240820)

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