What question did this study set out to answer?

This research aims to develop a photocatalytic method for facilitating α-amidyl radical cyclizations.

May 20, 2026Organic Chemistry Frontiers0 citations

Acridine/Lewis Acid Photocatalysis Enables α-Amidyl Radical Cyclizations

SJSaurav JoshiUniversity of Florida DRDillon RickertsenUniversity of Florida EGEmma GeorgeUniversity of Florida

Key Points

This research aims to develop a photocatalytic method for facilitating α-amidyl radical cyclizations.
Utilized Lewis acid-activated acridine as photocatalyst
Carried out intramolecular Giese-type cyclizations under mild photochemical conditions
Successfully demonstrated effective intramolecular Giese-type cyclizations of α-amidyl radicals
Reported advancement in addressing challenges related to α-amidyl radical reactivity

Abstract

A Lewis acid-activated acridine photocatalytic platform is reported that enables intramolecular Giese-type cyclizations of αamidyl radicals under mild photochemical conditions. This approach addresses longstanding challenges associated with αamidyl radical reactivity...

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