Key points are not available for this paper at this time.
Radio Frequency Identification (RFID) is a very promising wireless technology able to trace and track individual objects. The pharmaceutical supply chain is a challenging scenario, where an item-level traceability is crucial to guarantee transparency and safety in the drug flow. Unfortunately, there are still some barriers limiting the large-scale deployment of these innovative technologies. In order to face these challenges, multidisciplinary skills are required. A recent research project has attempted to coordinate heterogeneous activities focused on drug traceability. One of these is related to the evaluation of potential effects of exposure to electromagnetic fields on drugs. This paper aims to briefly describe both the main features of the defined framework for the item-level tracing of drugs on the whole supply chain and the most interesting results obtained by the evaluation of the potential effects of RFID systems on drugs. In particular, the potential alterations of the molecular structure of a commercial human insulin preparation have been analyzed by using investigative techniques such as Reverse Phase-High Pressure Liquid Chromatography and in vitro cell proliferation assays. The experimental results are strongly encouraging the use of RFID-based technologies for item-level tracing systems in the pharmaceutical supply chain.
Acierno et al. (Sat,) studied this question.