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The first complete guide to organizing and running cancer clinical trials, this book brings together in a single volume information on the fundamental concepts of trials, design, planning, conduct, and analysis that has previously ben scattered throughout medical and statistical literature. Topics covered include scientific background, ethical considerations, design and quality control, treatment toxicities and results in solid and non-solid tumors, preclinical and phase I trials, design of phase II trials, and analysis of phase III trials. The editors have updated the original 1984 text for this new paperback edition.
Ryzin et al. (Sun,) studied this question.