Long-term renal hypertension in rats led to a 30% increase in the average number of myocyte nuclei per cubic millimeter of myocytes across the ventricular wall.
Absolute Event Rate: 79240% vs 61012%
p-value: p=<0.0001
To determine whether long-term hypertension leads to hyperplasia of myocyte nuclei in the heart, a phenomenon suspected to occur in humans, renal hypertension was produced in rats and the animals were killed 8 mo later. Arterial blood pressure remained elevated for approximately 5 mo, but decreased progressively in the last 3 mo so that at 8 mo this parameter was practically identical to that found in controls. Moreover, left ventricular end diastolic pressure was markedly increased in experimental animals in association with a substantial decrease in left ventricular dP/dt. The alteration of these physiological measurements was indicative of severe ventricular dysfunction. Quantitative analysis of the transmural distribution of myocyte nuclei in the left ventricle showed 36 and 23% increases in myocyte nuclei concentration in the epimyocardium and endomyocardium, respectively. These changes in nuclei were accompanied by 25 and 16% reductions in myocyte cell volume per nucleus in the outer and inner layers of the wall. In conclusion, long-term hypertension leads to impairment of ventricular function and proliferation of nuclei in myocytes.
Anversa et al. (Sun,) conducted a other in Renal hypertension (n=28). Two-kidney, one-clip renal hypertension vs. Sham operation was evaluated on Average number of myocyte nuclei per cubic millimeter of myocytes across the ventricular wall (p=<0.0001). Long-term renal hypertension in rats led to a 30% increase in the average number of myocyte nuclei per cubic millimeter of myocytes across the ventricular wall.