Compressed SENSE accelerated 3D single-breath-hold LGE detected significantly more hyperenhancing lesions compared to conventional breath-hold LGE (13.8% vs. 12.1%) with superior scar edge sharpness.
Observational (n=101)
Single-blind
No
Does Compressed SENSE accelerated 3D single-breath-hold LGE improve lesion detection and image quality compared to conventional breath-hold LGE in patients with cardiomyopathies?
Compressed SENSE accelerated 3D single-breath-hold LGE provides comparable image quality and improved detection of smaller LGE lesions with superior scar edge sharpness compared to conventional multi-breath-hold LGE, potentially reducing CMR examination time.
Absolute Event Rate: 13.8% vs 12.1%
p-value: p=<0.0001
Aim The purpose of this study was to investigate the clinical application of Compressed SENSE accelerated single-breath-hold LGE with 3D isotropic resolution compared to conventional LGE imaging acquired in multiple breath-holds. Material Methods This was a retrospective, single-center study including 105 examinations of 101 patients (48.2 ± 16.8 years, 47 females). All patients underwent conventional breath-hold and 3D single-breath-hold (0.96 × 0.96 × 1.1 mm 3 reconstructed voxel size, Compressed SENSE factor 6.5) LGE sequences at 1.5 T in clinical routine for the evaluation of ischemic or non-ischemic cardiomyopathies. Two radiologists independently evaluated the left ventricle (LV) for the presence of hyperenhancing lesions in each sequence, including localization and transmural extent, while assessing their scar edge sharpness (SES). Confidence of LGE assessment, image quality (IQ), and artifacts were also rated. The impact of LV ejection fraction (LVEF), heart rate, body mass index (BMI), and gender as possible confounders on IQ, artifacts, and confidence of LGE assessment was evaluated employing ordinal logistic regression analysis. Results Using 3D single-breath-hold LGE readers detected more hyperenhancing lesions compared to conventional breath-hold LGE ( n = 246 vs. n = 216 of 1,785 analyzed segments, 13.8% vs. 12.1%; p 0.0001), pronounced at subendocardial, midmyocardial, and subepicardial localizations and for 1%–50% of transmural extent. SES was rated superior in 3D single-breath-hold LGE (4.1 ± 0.8 vs. 3.3 ± 0.8; p 0.001). 3D single-breath-hold LGE yielded more artifacts (3.8 ± 1.0 vs. 4.0 ± 3.8; p = 0.002) whereas IQ (4.1 ± 1.0 vs. 4.2 ± 0.9; p = 0.122) and confidence of LGE assessment (4.3 ± 0.9 vs. 4.3 ± 0.8; p = 0.374) were comparable between both techniques. Female gender negatively influenced artifacts in 3D single-breath-hold LGE ( p = 0.0028) while increased heart rate led to decreased IQ in conventional breath-hold LGE ( p = 0.0029). Conclusions In clinical routine, Compressed SENSE accelerated 3D single-breath-hold LGE yields image quality and confidence of LGE assessment comparable to conventional breath-hold LGE while providing improved delineation of smaller LGE lesions with superior scar edge sharpness. Given the fast acquisition of 3D single-breath-hold LGE, the technique holds potential to drastically reduce the examination time of CMR.
Gertz et al. (Thu,) conducted a observational in Ischemic or non-ischemic cardiomyopathies (n=101). Compressed SENSE accelerated 3D single-breath-hold LGE vs. Conventional breath-hold LGE was evaluated on Detection of hyperenhancing lesions (percentage of segments) (p=<0.0001). Compressed SENSE accelerated 3D single-breath-hold LGE detected significantly more hyperenhancing lesions compared to conventional breath-hold LGE (13.8% vs. 12.1%) with superior scar edge sharpness.