The Anatomy-Electrocardiogram Model (AEM) achieved an AUC of 0.8192 for incident heart failure prediction and a C-index of 0.6976 for survival prediction, outperforming state-of-the-art methods.
Observational
Does the Anatomy-Electrocardiogram Model (AEM) improve incident HF prediction and survival prediction compared to state-of-the-art multi-modal methods using paired 3D cardiac anatomy and ECG data?
The Anatomy-Electrocardiogram Model (AEM) effectively integrates 3D cardiac anatomy and 12-lead ECG data to improve the prediction of incident heart failure and survival.
Effect estimate: AUC 0.8192, C-index 0.6976
Cardiovascular disease (CVD) is one of the leading causes of death and illness across the world. Especially, early prediction of heart failure (HF) is complicated due to the heterogeneity of its clinical presentations and symptoms. These challenges underscore the need for a multidisciplinary approach for comprehensive evaluation of cardiac state. To this end, we specifically select electrocardiogram (ECG) and 3D cardiac anatomy for their complementary coverage of cardiac electrical activities and fine-grained structural modeling. Building upon this, we present a novel pre-training framework, named Anatomy-Electrocardiogram Model (AEM), to explore their complex interactions. AEM adopts a multi-task self-supervised scheme that combines a masked reconstruction objective with a cardiac measurement (CM) regression branch to embed cardiac functional priors and structural details. Unlike image-domain models that typically localize the whole heart within the image, our 3D anatomy is background-free and continuous in 3D space. Hence, the model can naturally concentrate on finer structures at the patch level. The further integration with ECG captures functional dynamics through electrical conduction, encapsulating holistic cardiac representations. Extensive experiments are conducted on the multi-modal datasets collected from the UK Biobank, which contain paired biventricular point cloud anatomy and 12-lead ECG data. Our proposed AEM achieves an area under the receiver operating characteristic curve of 0.8192 for incident HF prediction and a concordance index of 0.6976 for survival prediction under linear evaluation, outperforming the state-of-the-art multi-modal methods. Additionally, we study the interpretability of the disease prediction by observing that our model effectively recognizes clinically plausible patterns and exhibits a high association with clinical features.
Peng et al. (Sat,) conducted a observational in Heart failure. Anatomy-Electrocardiogram Model (AEM) vs. State-of-the-art multi-modal methods was evaluated on Incident HF prediction and survival prediction (AUC 0.8192, C-index 0.6976). The Anatomy-Electrocardiogram Model (AEM) achieved an AUC of 0.8192 for incident heart failure prediction and a C-index of 0.6976 for survival prediction, outperforming state-of-the-art methods.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: