His-bundle pacing combined with AVN ablation improved LVEF from 44.9% to 57.6% (P<0.001) over a median 3.0 years, with a 25.9% rate of heart failure hospitalization or all-cause mortality.
Cohort (n=94)
Does His-bundle pacing combined with AVN ablation improve outcomes in patients with atrial fibrillation and heart failure?
His-bundle pacing combined with AVN ablation significantly improves LVEF in patients with AF and HF, though those with lower baseline LVEF, higher PASP, or higher serum creatinine remain at higher risk for death or HF hospitalization.
AIMS: His-bundle pacing (HBP) combined with atrioventricular node (AVN) ablation has been demonstrated to be effective in patients with atrial fibrillation (AF) and heart failure (HF) during medium-term follow-up and there are limited data on the risk analysis of adverse prognosis in this population. In this study, we aimed to evaluate the long-term performance of HBP following AVN ablation in AF and HF. METHODS AND RESULTS: From August 2012 to December 2017, consecutive AF patients with HF and narrow QRS who underwent AVN ablation and HBP were enrolled. The clinical and echocardiographic data, pacing parameters, all-cause mortality, and heart failure hospitalization (HFH) were tracked. A total of 94 patients were enrolled (age 70.1 ± 10.5 years; male 57.4%). Acute HBP were achieved in 89 (94.7%) patients with successful permanent HBP combined with AVN ablation in 81 (86.2%) patients. Left ventricular ejection fraction (LVEF) improved from 44.9 ± 14.9% at baseline to 57.6 ± 12.5% during a median follow-up of 3.0 (IQR: 2.0-4.4) years (P < 0.001). Heart failure hospitalization or all-cause mortality occurred in 21 (25.9%) patients. The LVEF ≤ 40%, pulmonary artery systolic pressure (PASP) ≥40 mmHg, or serum creatinine (Scr) ≥97 μmol/L at baseline was significantly associated with higher composite endpoint of HFH or death (P < 0.05). The His capture threshold was 1.0 ± 0.7 V/0.5 ms at implant and remained stable during follow-up. CONCLUSION: His-bundle pacing combined with AVN ablation was effective in patients with AF and drug-refectory HF. High PASP, high Scr, or low LVEF at baseline was independent predictors of composite endpoint of all-cause mortality or HFH.
Su et al. (Fri,) conducted a cohort in atrial fibrillation and heart failure (n=94). His-bundle pacing combined with atrioventricular node ablation was evaluated on Heart failure hospitalization or all-cause mortality. His-bundle pacing combined with AVN ablation improved LVEF from 44.9% to 57.6% (P<0.001) over a median 3.0 years, with a 25.9% rate of heart failure hospitalization or all-cause mortality.