Women with polycystic ovary syndrome had a significantly increased risk of coronary artery calcification compared with unexposed women (OR 2.70; 95% CI 1.31-5.60).
Cohort (n=988)
Yes
Does polycystic ovary syndrome increase the risk of coronary artery calcification and carotid-intima-media thickness in women?
Women with full-phenotype polycystic ovary syndrome (both anovulation and hyperandrogenism) are at significantly increased risk for developing subclinical cardiovascular disease compared to unexposed women or those with only one manifestation.
Effect estimate: OR 2.70 (95% CI 1.31-5.60)
OBJECTIVE: To study the independent associations of polycystic ovary syndrome (PCOS), and its 2 components, hyperandrogenism and anovulation, with coronary artery calcification (CAC) and carotid artery intima-media thickness (IMT). APPROACH AND RESULTS: At the year 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort of young adults, women (mean age, 45 years) with information on menses and hirsutism in their twenties were assessed for CAC (n=982) and IMT (n=988). We defined PCOS as women who had both irregular menses and hyperandrogenism (n=55); isolated oligomenorrhea (n=103) as women who only had irregular menses; and isolated hyperandrogenism (n=156) as women who had either hirsutism or increased testosterone levels. Logistic regressions and general linear models were used to estimate the associations between components of PCOS and subclinical CVD. The prevalence of CAC was 10.3% overall. Women with PCOS had a multivariable adjusted odds ratio of 2.70 (95% confidence interval, 1.31-5.60) for CAC. Women with either isolated oligomenorrhea or isolated hyperandrogenism had no increased risk of CAC when compared with unexposed women. Women with PCOS had significantly increased bulb and internal carotid-IMT measurements; however, no significant differences were noted in bulb or internal carotid artery IMT among women with either isolated oligomenorrhea or isolated hyperandrogenism when compared with unexposed women. There were no differences in common carotid-IMT among the 4 study groups. CONCLUSIONS: In this study, women with PCOS, manifested as both anovulation and hyperandrogenism, but not women with one of these manifestations alone, were at increased risk for the development of subclinical CVD.
Calderon‐Margalit et al. (Fri,) conducted a cohort in Polycystic ovary syndrome (n=988). Polycystic ovary syndrome vs. Unexposed women was evaluated on Coronary artery calcification (CAC) (OR 2.70, 95% CI 1.31-5.60). Women with polycystic ovary syndrome had a significantly increased risk of coronary artery calcification compared with unexposed women (OR 2.70; 95% CI 1.31-5.60).