Left atrial strain demonstrated reasonable diagnostic performance for detecting heart failure with preserved ejection fraction, yielding an AUC of 0.83 in a meta-analysis of four studies.
Meta-Analysis (n=3,072)
Do novel echocardiographic markers accurately diagnose HFpEF and LVDD compared to cardiac catheterization?
Multivariable models and novel echocardiographic markers like left atrial strain and exercise E/e' show strong diagnostic performance for HFpEF and LVDD compared to invasive catheterization.
Effect estimate: AUC 0.83 (95% CI 0.70-0.95)
This study aimed to evaluate the diagnostic performance of echocardiographic markers of heart failure with preserved ejection fraction (HFpEF) and left ventricular diastolic dysfunction (LVDD) in comparison with the gold standard of cardiac catheterization. Diagnosing HFpEF is challenging, as symptoms are non-specific and often absent at rest. A clear need exists for sensitive echocardiographic markers to diagnose HFpEF. We systematically searched for studies testing the diagnostic value of novel echocardiographic markers for HFpEF and LVDD. Two investigators independently reviewed the studies and assessed the risk of bias. Results were meta-analysed when four or more studies reported a similar diagnostic measure. Of 353 studies, 20 fulfilled the eligibility criteria. The risk of bias was high especially in the patients' selection domain. The highest diagnostic performance was demonstrated by a multivariable model combining echocardiographic, clinical and arterial function markers with an area under the curve of 0.95 (95% CI, 0.89-0.98). A meta-analysis of four studies indicated a reasonable diagnostic performance for left atrial strain with an AUC of 0.83 (0.70-0.95), a specificity of 93% (95% CI, 90-97%) and a sensitivity of 77% (95% CI, 59-96%). Moreover, the addition of exercise E/e' improved the sensitivity of HFpEF diagnostic algorithms up to 90%, compared with 60 and 34% of guidelines alone. Despite the heterogeneity of the included studies, this review supported the current multivariable-based approach for the diagnosis of HFpEF and LVDD and showed a potential diagnostic role for exercise echocardiography and left atrial strain. Larger well-designed studies are needed to evaluate the incremental value of novel diagnostic tools to current diagnostic algorithms.
Canto et al. (Tue,) conducted a meta-analysis in Heart failure with preserved ejection fraction (HFpEF) and left ventricular diastolic dysfunction (LVDD) (n=3,072). Left atrial strain vs. Conventional echocardiographic markers / Cardiac catheterization was evaluated on Diagnostic performance (Area Under the Curve) for HFpEF (AUC 0.83, 95% CI 0.70-0.95). Left atrial strain demonstrated reasonable diagnostic performance for detecting heart failure with preserved ejection fraction, yielding an AUC of 0.83 in a meta-analysis of four studies.