In patients with atrial fibrillation, hypertension with baseline systolic blood pressure ≥150 mm Hg was associated with a higher incidence of stroke/SE (HR 1.74; 95% CI 1.08-2.72) and major bleeding.
Cohort (n=3,713)
No
Does elevated systolic blood pressure (≥150 mm Hg) increase the risk of stroke/systemic embolism or major bleeding in patients with atrial fibrillation and hypertension?
In patients with atrial fibrillation, a history of hypertension alone does not increase stroke or bleeding risk, but uncontrolled systolic blood pressure ≥150 mm Hg significantly increases both risks.
Effect estimate: HR 1.74 (95% CI 1.08-2.72)
BACKGROUND: Hypertension is considered a major risk factor of stroke and systemic embolism (SE) as well as bleeding in patients with atrial fibrillation (AF). The purpose of this study was to investigate the relationship of hypertension and systolic blood pressure (SBP) with the risk of stroke/SE or bleeding in AF patients. METHODS: The Fushimi AF Registry, a community-based prospective survey, was designed to enroll all of the AF patients in Fushimi-ku, Kyoto. Fushimi-ku is densely populated with a total population of 283,000. Follow-up data were available for 3,713 patients (follow-up rate 90.0%) as of August 2015, and the median follow-up period was 1,035 days. RESULTS: We compared the clinical backgrounds at baseline, and follow-up outcomes of AF patients between those with hypertension (HTN; n = 2,304, 62.1% of total) and those without (non-HTN; n = 1,409). History of hypertension was neither associated with the incidence of stroke/SE, ischemic stroke, hemorrhagic stroke nor major bleeding. However, when we divided the HTN group by baseline SBP ≥150 mm Hg (HTN-high blood pressure HBP: n = 305, 13.3% of HTN group) or <150 mm Hg (HTN-low blood pressure LBP: n = 1,983), HTN-HBP group was significantly associated with a higher incidence of both stroke/SE (hazard ratio HR: 1.74, 95% confidence interval CI: 1.08-2.72) and major bleeding (HR: 2.01, 95% CI: 1.21-3.23) compared with the non-HTN group. In contrast, HTN-LBP group was not associated with the risk of stroke/SE or major bleeding, compared with the non-HTN group. CONCLUSION: The incidences of stroke/SE and bleeding were higher in AF and hypertension patients with elevated SBP. UMIN Clinical Trials Registry: UMIN000005834.
Ishii et al. (Thu,) conducted a cohort in Atrial fibrillation (n=3,713). Hypertension with baseline SBP ≥150 mm Hg vs. No hypertension was evaluated on Stroke or systemic embolism (HR 1.74, 95% CI 1.08-2.72). In patients with atrial fibrillation, hypertension with baseline systolic blood pressure ≥150 mm Hg was associated with a higher incidence of stroke/SE (HR 1.74; 95% CI 1.08-2.72) and major bleeding.
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