The CONCORD study is designed to compare the diagnostic accuracy of cardiovascular magnetic resonance versus CCTA with FFRCT against invasive FFR in 300 patients with suspected angina.
Observational (n=300)
No
Does cardiovascular magnetic resonance or coronary computed tomography angiography with fractional flow reserve provide better diagnostic accuracy for obstructive coronary artery disease in patients with suspected angina?
The CONCORD study will evaluate the comparative diagnostic accuracy of CMR versus CCTA/FFR CT against invasive FFR in patients with suspected angina and moderate-high risk of CAD.
In patients with suspected coronary artery disease (CAD), the optimal diagnostic algorithm remains uncertain. Non-invasive imaging plays a central role as a “gatekeeper” to invasive coronary angiography, with both cardiovascular magnetic resonance (CMR) and coronary computed tomography angiography (CCTA) with fractional flow reserve (FFR CT ) proving effective in reducing unnecessary invasive procedures. However, direct comparisons between the two modalities are limited. CONCORD is a prospective, single-center study comparing the diagnostic accuracy of CMR and CCTA/FFR CT to detect obstructive CAD in 300 patients with suspected angina referred for clinically indicated invasive coronary angiography. The primary outcome is the diagnostic accuracy of each imaging protocol against the reference standard of invasive fractional flow reserve. Key secondary outcomes include whether quantitative CMR is more accurate than qualitative CMR and/or CCTA/FFR CT, and whether hybrid imaging models may outperform single modality strategies (NCT04761991). CONCORD will comprehensively evaluate two frontline non-invasive functional imaging modalities in patients with suspected angina and determine the comparative accuracy of CCTA/FFR CT and CMR in patients with a moderate-high risk of CAD. Evaluation of these strategies has the potential to inform both the quality and cost-effectiveness of imaging services.
Shergill et al. (Fri,) conducted a observational in Suspected coronary artery disease (n=300). Cardiovascular magnetic resonance (CMR) vs. Coronary computed tomography angiography (CCTA) with fractional flow reserve (FFRCT) was evaluated on Diagnostic accuracy of each imaging protocol against the reference standard of invasive fractional flow reserve. The CONCORD study is designed to compare the diagnostic accuracy of cardiovascular magnetic resonance versus CCTA with FFRCT against invasive FFR in 300 patients with suspected angina.