Baseline left ventricular global longitudinal strain was an independent predictor of left ventricular reverse remodeling (HR 1.474) in patients with dilated cardiomyopathy and sinus rhythm.
Cohort (n=160)
No
Does baseline LV GLS predict left ventricular reverse remodeling in patients with dilated cardiomyopathy and sinus rhythm?
Baseline LV GLS is an independent predictor of left ventricular reverse remodeling in patients with dilated cardiomyopathy, with an optimal cut-off of -10%.
Effect estimate: HR 1.474 (95% CI 1.170-1.856)
p-value: p=0.001
BACKGROUND: A considerable number of patients with dilated cardiomyopathy (DCM) experience left ventricular reverse remodeling (LVRR). LV global longitudinal strain (LV GLS) offers sensitive and reproducible measurement of myocardial dysfunction. The authors sought to evaluate whether LV GLS at the time of diagnosis may predict LVRR in DCM patients with sinus rhythm and investigate its prognostic role in long-term follow-up in this population. METHODS: We enrolled 160 DCM patients with sinus rhythm who had been initially diagnosed, evaluated, and followed at our institute. We analyzed their medical records and echocardiographic data. RESULTS: During the mean follow-up duration of 37.3 ± 21.7 months, LVRR occurred in 28% of patients (n = 45). The initial LV ejection fraction (LVEF) of patients who recovered LV function was 26.1 ± 7.9%, which was not significantly different from the value of 27.1 ± 7.4% (p = 0.49) in those who did not recover. There was a moderate and highly significant correlation between baseline LV GLS (-%) and follow-up LVEF (r = 0.717; p < 0.001). Using multivariate Cox analysis, LV GLS (hazard ratio: 1.474, 95% confidence interval: 1.170-1.856; p = 0.001) was an independent predictor of LVRR. CONCLUSIONS: We demonstrated that LV GLS was an independent predictor for LVRR and the optimal cut-off point of LV GLS for LVRR was -10% in DCM patients with sinus rhythm. There was a significant correlation between baseline LV GLS and follow-up LVEF.
Jung et al. (Wed,) conducted a cohort in Dilated Cardiomyopathy (n=160). Left Ventricular Global Longitudinal Strain (LV GLS) was evaluated on Left ventricular reverse remodeling (LVRR) (HR 1.474, 95% CI 1.170-1.856, p=0.001). Baseline left ventricular global longitudinal strain was an independent predictor of left ventricular reverse remodeling (HR 1.474) in patients with dilated cardiomyopathy and sinus rhythm.