Recent advances in Epstein–Barr virus vaccines development from mechanistic exploration to clinical translation

Key Points

• The review aims to summarize recent advancements in the understanding and development of vaccines against Epstein–Barr virus.
• Overview of EBV biology and recent findings related to vaccine development.
• Discussion of vaccine platforms including mRNA and nanoparticles.
• Examination of antigen selection processes and immunological implications.
• Identified key mechanisms for EBV vaccine targets using innovative platforms.
• Discussed challenges in translating research into available vaccines.
• Outlined future directions for effective EBV vaccine development.