Covalent DNA-Streptavidin Conjugates as Building Blocks for Novel Biometallic Nanostructures

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Abstract

Supramolecular aggregates of DNA, RNA, streptavidin, immunoglobulin, and nanocrystalline metal clusters can be generated by self-assembly on the basis of oligonucleotide hybridization (shown schematically). Following selective immunosorption on surface-immobilized antigen, the biometallic hybrid is detectable by electron microscopy.

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Journals

Angewandte Chemie International Edition

Institutions

University of Bremen

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